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Let's look at some of the clinical studies that back this up

Therefore, our initial investigation set out to provide a comprehensive analysis of the potency of tirzepatide at the mGIPR to identify potential limitations of using mouse models to study the actions of tirzepatide

This was associated with substantive mobility of the RAMP2 linker and TM helix, which had weaker interaction with the CTR TM bundle compared to RAMP1 and RAMP3 in AMY 1 R and AMY 3 R complexes