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7% with placebo, constipation (8%, 17% and 14%) vs

In COVID-19 patients, an increase in inflammatory cytokines, such as interleukin 6 (IL-6), IL-2, IL-7, IL-10, granulocyte colony-stimulating factor (GCSF), interferon -induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1-alpha (MIP1A), and tumor necrosis factor (TNF-), is observed which is called cytokine storm [5]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Pratley R, Amod A, Hoff ST, et al

More importantly, avoid large meals within 34 hours of bedtime to minimize gastric discomfort and reflux symptoms