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[ [PMID: 35441470] et al

Aromatase inhibitors like letrozole block local estrogen production in lesions and may help when other treatments fail, though they're used off-label and require bone density monitoring

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In these patients, especially those with heart or kidney disease, the drugs improved blood sugar control, reduced the risk of heart and kidney complications, supported weight loss, and lowered the risk of early death

While this has not been conclusively confirmed in humans, the medication is contraindicated in patients with a personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)