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Contraindications: pregnancy and breastfeeding (no reproductive data), active cancer or cancer history (angiogenesis could theoretically feed tumor growth), children under 18 (no pediatric data)

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Overall, while these findings demonstrate promising neuroprotective effects, the pharmacokinetics, long-term biodistribution, and potential off-target toxicity of CQDs remain largely unexplored, highlighting the need for more relevant studies prior to clinical application