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The rate of HNB tobacco users was relatively lower relative to other products, at 1.3% (95% CI: 1.3, 1.3)/0.9% (95% CI: 0.9, 0.9)/1.1% (95% CI: 1.0, 1.2) among junior high school students, and 2.9% (95% CI: 2.8, 3.0)/1.4% (95% CI: 1.4, 1.4)/2.2% (95% CI: 2.0, 2.4) among high school students

Regul Toxicol Pharmacol 95:102114

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Daniel McGehee and colleagues at the University of Chicago have shown that along with directly stimulating the brains reward system, nicotine also stimulates it indirectly by altering the balance of inputs from two types of neurons that help regulate its activity level