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These observations are very important as lactate does not only act as an osmolyte but is also an essential energy metabolite, reflecting potential cerebral energy impairment in patients with HE

In the STEP trials, semaglutide 2.4 mg weekly showed average weight reductions of 1215% of body weight over 68 weeks, whilst in the SCALE trials, liraglutide 3 mg daily typically produced 58% weight loss

Given that the efficacy of these nutrients in treating DED has been thoroughly explored through reviews and meta-analyses, this review will focus on elucidating their mechanisms of action and potential health risks

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Once activated, it enhances signal transduction pathways that restore cellular ATP levels, including fatty acid oxidation and autophagy[15]