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Glucagon stimulates hepatic glucose production, which can have adverse effects on plasma glucose concentrations that are offset by the beneficial effects of weight loss, and decreases intrahepatic triglyceride content (mediated by increased intrahepatic triglyceride lipolysis, fatty acid oxidation, and ketogenesis and decreased de novo lipogenesis) and decreases plasma LDL-cholesterol concentration (mediated by increased hepatic LDL receptor activity)

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