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These three genes are therefore sufficient to explain the presence of the ascorbate-glutathione cycle in these compartments (Foyer and Halliwell, 2

Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei

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GRP is widely distributed in lung and gastrointestinal tracts