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Cantaert et al

The label states that a lower initial warfarin dose should be considered for patients with certain genetic variations

however, they do so through different biological pathways

Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]