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We found that PA-S14 promotes mitochondrial biogenesis via LKB1-AMPK-PGC-1 signaling pathway, which protects against renal TECs cell senescence, renal fibrosis in various CKD models, such as unilateral ureteral obstruction (UUO), unilateral ischemia-reperfusion injury (UIRI), adriamycin nephropathy and 5/6 nephrectomized model (Table 1)

Significance was determined by unpaired two-tailed Students t -test ( d , j , k ), two-way ANOVA with uncorrected Fishers LSD ( f , g ) and simple linear regression ( l , m , n )

S8, B and D) did not change synaptically evoked glutamate transients

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Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, et al