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In trials of dapagliflozin, canagliflozin, or empagliflozin in combination with metformin as initial combination therapy, there were no significant differences in the incidence of hypoglycemia between canagliflozin plus metformin vs

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8 The GLP-1 agonists are associated with adverse gastrointestinal effects such as nausea, vomiting and delayed gastric emptying (see table)