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The MHRA will continue to closely monitor the risk of severe psychiatric reactions associated with these medicines and will assess new data as it becomes available

Additionally, berberine and other patch ingredients can cause side effects such as: Upset stomach Diarrhea Constipation Excess gas The severity and duration of these side effects are uncertain, unlike GLP-1 injections, whose side effects are well-documented and tend to stabilize over time

Whilst mild headaches during GLP-1 therapy often resolve spontaneously or respond to simple measures, certain circumstances warrant prompt medical evaluation

doi: 10.1038/ajg.2012.300

Do not shake the vial aggressively