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BMC Ophthalmol 2023;23:368

Standard practice includes: Baseline thyroid function tests (TSH and free T4) before initiating GLP-1 therapy Repeat testing at 812 weeks after starting treatment or after dose escalation Regular monitoring every 36 months during active weight loss Return to annual monitoring once weight is stable and thyroid function remains consistent Adjustments to levothyroxine dosing may be necessary as weight changes

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Diagram 2: Central sexual-desire pathway Likewise, Illustrate bremelanotide entering central signaling pathways, activating MC4R-associated neurons in the medial preoptic area and hypothalamus, increasing dopamine-associated motivation signaling, and influencing desire and arousal