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It will evaluate the real-world effectiveness of tirzepatide in weight loss, prevention of diabetes and obesity-related complications, and also collect data on healthcare resource utilisation, health-related quality of life, participants employment status and sick days

The key is informed consent

"With high demand, falling prices and multiple brands, you may see direct pharmacy purchases, distributor-level leakages, or cosmetic or lifestyle use especially in urban markets," said Salil Kallianpur, an independent analyst

Certainly hypothyroidism, or having too low levels of thyroid hormone, can make weight loss more challenging and can predispose to a little bit of weight gain, Dominguez says

The study was conducted in accordance with the ethical principles that have their origins in the Declaration of Helsinki and its subsequent amendments (clinicaltrials.gov identifier NCT02317536)