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What McGuire and his colleagues found as they read through the literature was a decidedly mixed bag

As expected, the engineered strain W303-1b/FGP presented the highest yield of GSH

Another reading suggests that broad gene-expression effects can reflect secondary consequences (changes in cell state, in proliferation rate, in metabolism) rather than direct mechanism-based effects, and that the specificity of the transcriptomic findings should be interpreted with caution