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Notably, when Melanotan II-treated mice were compared to vehicle-treated pair-fed mice that lost equivalent body weight through caloric restriction, the Melanotan II group showed greater reductions in subcutaneous adipose tissue, suggesting effects beyond simple appetite suppression

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Older oral anti-obesity agents phentermine-topiramate extended release, naltrexone-bupropion, orlistat have smaller mean effects but are often available at far lower cost, sometimes as generics

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