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These medications interact with the brain reward system , energy metabolism , gastrointestinal function , and hormonal pathways that govern everything from appetite to arousal
However, its increasing off-label use for rapid weight loss has brought attention to its unintended effects on facial esthetics and skin health
In the STEP trials, semaglutide produced average weight loss of 1518% at the 2.4 mg maintenance dose, with approximately 80% of participants achieving clinically significant (5%) weight loss
By activating GLP-1 receptors in the brain, particularly in areas that regulate appetite, Wegovy helps to reduce hunger and increase feelings of fullness