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Because of their already highly sensitized bodies and a low threshold of stimulatory excitation response, any product including methylated folate or methylated B12 can further increase an excitation response and trigger an adrenal crash

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This led to the development of GHRP-6, the first widely studied growth hormone releasing peptide, followed by GHRP-2 (more potent) and hexarelin (most potent for GH release)

Human data is limited to two PK/PD studies and a discontinued Phase II trial