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However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]

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I.et al (1999)

Several glycolytic enzymes, including solute carrier family 2 (facilitated glucose transporter), member 1 ( Glut1 ), hexokinase 1 and 2 ( Hk1/2 ), glucose phosphate isomerase 1 ( Gpi1 ), 6-phospho-fructo-kinase/fructose-2,6-bisphosphatase 2 and 4 ( Pfkfb2 / 4 ), aldolase a ( Aldoa ), enolase 2 and 4 ( Eno1 / 4 ), and pyruvate kinase M2 ( Pkm2 ), were shown via ChIP sequencing to be differentially regulated by NRF2 in the esophagus of postnatal day 7 Nrf2 / and Keap1 / mouse pups compared with the wild type (56)

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