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For example, the p53 mutants p53 R 237 H and p53 R 175 H promote sensitivity to ferroptosis-like cell death, most likely through the combination of p53 mutants with NRF2 and through the suppression of the NRF2-dependent transactivation of SLC7A11 together with other antioxidant genes that oppose ferroptosis (Sasaki et al., 2002

In UC patients, there is reduced diversity of intestinal flora, altered types and quantities of intestinal flora, and increased infiltration of mucosal CD4+ T cells in the inflammatory areas

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The intestinal flora also plays an important role in other PPI-mediated diseases