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Islet exposure to cytokines triggers nuclear factor B (NFB) induction of inducible nitric oxide synthase (iNOS), which increases NO formation in the beta-cell (87)

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All individuals were anesthetized with medetomidine (Domitor, Nippon Zenyaku Kogyo Co., Ltd, Fukushima, Japan) [0.05 mg/kg intramuscularly (IM)] and ketamine hydrochloride (Ketalar, Daiichi Sankyo Co., LTD, Tokyo, Japan) (10 mg/kg IM), and then veterinarians pressed their bladders gently to collect their urine samples

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