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as described by Falanga and colleagues, TfR is expressed highly in bone marrow, immune system, and female tissues, moderately in brain, endocrine tissues, lung, gastrointestinal tract, kidney, urinary bladder, male tissues, and skin, and low in muscle tissues, liver, gallbladder, adipose, and soft tissue, aside from serum [21]

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It is only approved for type 2 diabetes

Impact of MTHFR gene variants on health The most studied variants of the MTHFR gene canb reduce enzyme activity by 20-80%