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While traditionally considered first-line therapy, current American Diabetes Association guidance emphasizes a person-centered approach to initial medication selection based on comorbidities, treatment goals, and patient preferences

doi: 10.1016/j.cell.2019.06.007 164 LiuBCarlsonRJPiresISGentiliMFengEHellierQet al

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Fatty acids as modulators of the immune response

This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)