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Recent reports elucidated that HSPA5 upregulation negatively regulates ferroptosis in pancreatic cancer, while ATF4 activation upregulates HSPA5, thus the HSPA5-GPX4 pathway is one of the causes of gemcitabine resistance (Zhu S

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161 In addition, some evidence suggests the combination of excess folic acid plus B 12 deficiency may cause more neurological harm than B 12 deficiency alone