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Lysine is also a precursor to carnitine, which is needed for fat metabolism and energy production

Lola Fs, Monika Tu, Karolina Kaczmarska, Katarzyna Sanchez, Abhiyan Viplav, Ph.D., Tina el, Rositsa Hadzhipetrova #InSphero #LiverSafety #InVitroToxicology #Hepatotoxicity #DILI #3DCellCulture To view or add a comment, sign in A compound clears safety pharmacology, then Phase 1 comes back with diarrhea and related adverse events

This means oral BPC-157 capsules can reach the gastric and intestinal mucosa in their intact, pharmacologically active form, unlike insulin, growth hormone, or GLP-1 analogs (unless specially formulated), which are immediately destroyed by gastric acid

doi: 10.1024/0300-9831/a000149 206

The mechanism of this pathway requires a high concentration of glucose which is then converted to sorbitol by utilizing the enzyme Aldose reductase requiring coenzyme NADPH oxidized to NADP + (Yan 2018)