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Tissue-specific enzyme prohormone convertases (PC) 1/3 and PC2 further cleave proglucagon at pairs of dibasic amino acid sequences, except at the GLP-1 NH 2 -terminal site represented by a single Arg residue ( Figure 1A )

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The compound bisdemethoxycurcumin was found to be the most effective in reducing MDR-1 gene expression in comparison with pure curcumin and demethoxycurcumin