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GHK-Cu addresses the collagen rebuilding pathway directly, works without the irritation risk of retinol (which many midlife women can no longer tolerate), and has anti-inflammatory properties that benefit reactive, sensitised skin during hormonal transition

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doi: 10.3389/fnut.2025.1679381 Received 04 August 2025 Revised 08 November 2025 Accepted 14 November 2025 Published 01 December 2025 Volume 12 - 2025 Edited by Maria Morgan-Bathke, Viterbo University, United States Reviewed by Mohammed Faris Abdulghani, University of Nineveh, Iraq Saeid Shamlou Kazemi, Bu-Ali Sina University, Iran Updates Copyright 2025 Lei and Rezaei

These effects can be reversed by ferroptosis inhibitors DFO and Fer-1, 110 indicating that the combination of cetuximab and -elemene inhibits EMT by promoting ferroptosis

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