Clinical criteria typically include a documented BMI of 30 or higher, or 27 or higher with a related comorbidity
When external fatty acids enter the cytosol, they are converted by acyl-CoA synthetase long-chain family members (ACSLs) into fatty acyl-CoA, which serves as a substrate for lipid metabolism and membrane biogenesis
Emerging Systemic Therapies for Colorectal Cancer
Actin-like protein 6A (ACTL6A), also known as 53 kDa BRG-1/human BRM-associated factor (BAF53a), is involved in diverse cellular processes, such as vesicular transport, spindle orientation, nuclear migration, the cell cycle, and chromatin remodeling 6,7,8,9
Early clinical studies in Barth syndrome, primary mitochondrial myopathies, and age-related macular degeneration have shown favorable safety, tolerability, and signals of efficacy (Thompson et al., 2024)