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Of note, in the STEP 1 extension trial, participants regained roughly two-thirds of their lost weight within a year of stopping semaglutide, and improvements in blood pressure, cholesterol, and glucose largely reversed

Quantification was performed on three slides from each brain blinded to the study groups

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Chromatography was performed with an AKTAexplorer 10 S fast protein liquid chromatography (FPLC) system (GE Healthcare Life Sciences)

Ischaemic optic neuropathy occurs when the blood supply to the optic nerve, the structure that carries visual information from the eye to the brain, is reduced