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A recent study suggested that there may be multiple reasons for remyelination failure in MS patients, according to lesion stage: in a subset of active lesions, a lack of myelin sheath formation was observed despite the presence of mature OLGs, whereas in inactive lesions, OLG loss and a hostile microenvironment were identified as the major causes of remyelination failure (He et al., Subcortical lesions display more extensive remyelination than periventricular and cerebellar lesions, which are often poorly remyelinated (Goldschmidt et al., 2017), as clearly shown by the analysis of leukocortical regions, which embrace both white and gray matter (Chang et al., 2001

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