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Topical GHK-Cu produces negligible serum concentrations (less than 1% bioavailability) but creates a prolonged dermal reservoir, with peptide detectable in skin biopsies for 4896 hours

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Consistent therapy helps navigate these phases

The heterogeneous modulation of PKC isoforms by diacylglycerol, phospholipids, and calcium (Ca 2+ ) results in heterogeneity in their morphology, intracellular distribution, expression, precursor utilization, and stimulation mechanisms [142]

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