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PKA phosphorylates Ser133 of cyclic AMP-responsive element-binding protein (CREB) and SIK dephosphorylates Ser171 of CREB-regulated transcription co-activator (CRTC)

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The thermosensitive formulation combines curcumins antioxidant and anti-inflammatory properties with the moisture-retaining capability of alginate to expedite the wound healing process (288)

The methyl donor for this reaction is S-adenosylmethionine (SAM or AdoMet) and the reaction is catalyzed by the enzyme guanidinoacetate N -methyltransferase