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The fatty acid moiety and the linking chemistry to GLP-1 were the key features to secure high albumin affinity and GLP-1 receptor (GLP-1R) potency and in obtaining a prolonged exposure and action of the GLP-1 analogue

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Mounjaro and Zepbound also mimic GLP-1, along with a related hormone called glucose-dependent insulinotropic peptide, or GIP

Long-term hyperglycemia can contribute to persistent disturbances in glutamatergic signaling and neural damage in the medial prefrontal cortex, contributing to depressive behaviors [91]

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