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However, FDA has separately identified product quality as a documented concern category for compounded GLP-1 products generally, including contamination and variable potency

It states that lower insulin sensitivity may benefit more from combined GIP and GLP-1 effects on glucose handling, and that tirzepatide may offer stronger insulin-independent metabolic benefits

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Similarly, in SURMOUNT-4 (tirzepatide), participants completed a 36-week open-label lead-in to 10 or 15 mg, after which they were randomized to continue tirzepatide or switch abruptly to placebo

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