Liu X, Yao X, OuYang Q, Oliveira AL, Yan L, Zhang Y
It is not approved for human or veterinary use and is not intended for clinical administration, therapeutic treatment, or diagnostic procedures
This work was supported by Basic Scientific Research Fund of Education Department of Liaoning Province, China (LJ212410161100 to Z-LL), Natural Science Foundation of Liaoning Province, China (2022-MS-326 to Z-LL), and Dalian Medical University's "Integrated Traditional Chinese and Western Medicine " Open Fund Project (ZXY2025JC04 to Z-LL)
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If SCoV2 is targeting GSH biosynthesis as well as TXNRD1 and GPx1 for proteolytic knockdown, in infected cells, the resulting decreases in these critical antioxidant molecules would contribute to increased oxidative stress, NF-B activation and pro-apoptotic signaling ( these consequences of virus-mediated proteolysis would be taking place in everyone who is actively infected, regardless of their Se status , and would thus be consistent with results suggesting that Se intakes up to several times the minimal dietary requirement are associated with an increase in cure rate from COVID-19 (Figure 2) and the stochastic nature of such molecular interactions