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The dynamics of this first wave of offpatent entrants will be shaped not just by the cost of development, but also by regulatory classification, privatemarket affordability, and innovators ability to segment the market with second brands and nextgeneration therapies

While pregnancy rates have not been precisely measured in clinical trials, reproductive health experts recommend using backup contraception methods or switching to long-acting reversible options when taking semaglutide injections

This knowledge not only guides clinicians in prescribing the drug but also empowers patients to make informed decisions about their treatment options

Lincoff AM, Brown-Frandsen K, Colhoun HM et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes

Atomic coordinates have been deposited in the Protein Data Bank under the accession code 9MUN (GSSG-bound SLC33A1 MAP )