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Angelman syndrome (AS) , characterized by microcephaly, seizures, motor dysfunction, and mental retardation, is a result of maternal chromosome deletions in the region 15q11-q13 associated with ubiquitin-protein ligase E3A (UBE3A) critical region [379] Angelman syndrome (AS) UBE3A encodes E6-associated protein (E6-AP), which acts as a cellular ubiquitin ligase and establishes a covalent linkage between a 76-amino acid ubiquitin molecule and its target protein to form a polyubiquitylated substrate [379]

CAS No.: 75017-02-6 Formula: C 22 H 28 N 4 O 8 S 2 Molecular Weight:540.61 Storage: Please store the product under the recommended conditions in the Certificate of Analysis

Supplementation with antioxidant vitamins can effectively reduce dysmenorrhea severity, ameliorate chronic pelvic pain, and enhance the quality of life for these patients (112)

Mitchell, S