Mechanistic studies indicate that GLP-1RAs suppress the perception of all basic taste modalities, probably through combined actions in the brainstem and vagal modulation, although paradoxical cases of sweet hypersensitivity have been documented in specific populations (162)
Other notable greenlights this year include Bristol Myers Squibbs Cobenfy, the first novel therapeutic for schizophrenia in 35 years, and Madrigal Pharmaceuticals Rezdiffra, the first-ever treatment for MASH
The increase is dose-dependant
Steinert JR, Amal H (2022) The Contribution of an Imbalanced Redox Signalling to Neurological and Neurodegenerative Conditions
En pacientes previamente tratados con metformina y/o sulfonilureas la adicin de por lo menos 3 aos con GLP1-RA, evidencindose una mejora de marcadores lipdicos como triacilglicridos (-12%), colesterol total (-5%), LDL (-6%) y HDL (+24%) 149