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Thats especially true for people with digestive issues or certain medications

Drugs for rheumatoid arthritis, ulcerative colitis, and seizures can interfere with absorption

When intestinal damage is triggered by MTX, oxidative stress, a consequence of an imbalance between ROS and the bodys natural antioxidant defense mechanism, is developed and plays a crucial role (Zhang et al

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However, it remains unclear whether copper alone, or in combination with iron, triggers this process, as both metals are present in the liver of Wilson disease patients [21,27,45,47,50,52]