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The dose is then increased to 5 mg once weekly, with further escalation in 2.5 mg increments every four weeks as needed, based on glycemic response and tolerability, up to a maximum of 15 mg once weekly

197,198 Regulated in development and DNA damage response-1 (REDD1) is a stress response gene that can regulate development and the response to DNA damage

Studies have shown that the iron-sequestering ferritin H chain (FTH) is synthesized in hepatocytes to limit iron-induced hepatic glucose-6-phosphatase (G6Pase) expression and oxidative inhibition