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This, when applied to human skin, can help explain how omega-3 fatty acids help in hydration of the skin cells

Networks of WRKY transcription factors in defense signaling

As a conserved energy sensor, AMPK regulates key biological processes including glucose/lipid metabolism, inflammation, and autophagy by responding to cellular energy status (via AMP/ATP ratios) (Steinberg and Hardie, 2023

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These receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous system (specifically cells of the tuberomammillary nucleus of the hypothalamus), both airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils, dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems