The Short Answer: Yes, It Can Make You Tired
The semaglutide plateau phenomenon parallels the tirzepatide not working anymore experience, and in both cases, proper hydration is one factor worth examining
If you experience sustained weight loss plateau after 812 weeks on a stable tirzepatide dose, your provider may recommend gradual dose escalation or adjunct strategiesnot switching back to monotherapy
In patients with obesity, significant weight reduction achieved with GLP-1 therapy has been associated with improvements in sex hormone-binding globulin (SHBG) levels, reductions in free testosterone in women with hyperandrogenism, and normalization of menstrual cycles in some individuals with polycystic ovary syndrome (PCOS)
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