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Early pregnancy losses and increased incidences of minor visceral (kidney, liver) and skeletal (sternebra) fetal abnormalities were observed at 0.0025 mg/kg/day, at clinically relevant exposures

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In clinical trials of Wegovy (a semaglutide medication), participants lost an average of 15% of their body weight (approximately 33 pounds, though individual results varied) within 68 weeks

Amenorrhea which is not due to another underlying cause, as long as the individual is at least 15 years old or at least 3 years post thelarche