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Plaintiffs argue that the manufacturers knew or should have known about these risks based on clinical data, adverse event reports, medical literature, and post-market safety information

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16,51 The anxiolytic effect of GLP-1 agonists has been hypothesized due to the preservation of brain-derived neurotrophic factor/nuclear factor erythroid 2related factor 2 levels, decreased oxidative stress, and lipocalin 2 levels in the hippocampus