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Conversion of O to H 2 O 2 is performed by the cyclic oxidation of the Cu 2+ or Mn 2+ transition metal ion localized in the SOD active site (42, 47)

The metabolite network was predominantly characterized by Neuroactive ligand-receptor interaction, Prostaglandin E2, Efferocytosis, and L-Aspartic acid (shown in Fig

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