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Various physiological roles of TAU have been suggested, including calcium modulation, membrane stabilization, intracellular osmotic regulation and the regulation of protein phosphorylation 7, 8, 9, 10, 11, 12

Furthermore, alcohol may more specifically affect ghrelin, but not other gut peptides like GLP-1, insulin and PPY (Calissendorff et al., 2007

The SUSTAIN 29,30,31,32,33,34,35 and SCALE studies 10,11,12,13,14,15 have shown robust efficacy in lowering blood glucose levels in diabetic patients and inducing weight loss in obese patients over clinical trial periods ranging from 30 to 104 weeks

10.1016/j.jhep.2008.01.035 193

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