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As a result, whereas in most somatic cells G6PD is subject to turnover, in red blood cells any G6PD molecule undergoing denaturation or proteolytic breakdown cannot be replaced (this condition is true, of course, not only for G6PD but also for most other red blood cell enzymes )

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In addition to increased transcription of NRF2 target genes, livers from Gclc KO mice had lower expression of lipogenic genes and proteins (Fig

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