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Yes, metformin is still first-line for many patients, especially those without significant cardiovascular or renal risk

The 12.5 mg pen is blue

On average, visible skin changes (like brightness and improved tone) appear within 612 weeks of consistent use, but internal benefits like detox and immune support start sooner

TNF- has been identified as a major regulator of inflammation and a key player in the cytokine network 38

The analysis presented here suggests that although both compounds are safe and offer substantial health benefits and are involved in both autophagy and mitophagy, the role of UroA in mitophagy places it as a targeted intervention for mitochondrial health, whereas the broader influence of spermidine on autophagy and metabolic regulation may provide more comprehensive anti-ageing effects