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doi: 10.1021/acs.jmedchem.5b00726 22 RubinoDMGreenwayFLKhalidUONeilPMRosenstockJSrrigRet al

Parallel studies indicate that physiologic dopamine signaling generally inhibits NLRP3 activity via receptor-mediated pathways, implying that the gradual loss of dopamine in PD removes an endogenous anti-inflammatory brake, exacerbating neuroinflammation

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