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4) in exchange for malate imported into the mitochondria

Total weekly doses in the range of 510 mg, divided into 23 applications, are most frequently cited

Figure 1: Folate metabolism starts with polyglutamate folates (a form of Vitamin B9), which are broken down by the enzyme dihydrofolate reductase (DHFR) into dihydrofolate and then tetrahydrofolate (THF)